Endocrine Abstracts

Leptin acts not only as an anorexigenic hormone but is also involved in the regulation of cell-mediated immunity. However, since the impact of leptin on NK cells is currently elusive, we investigated the body weight-dependent leptin effects on NK cells numbers and function.In a first set of experiments leptin and MADB106 tumor cells were injected intravenously in male lean and diet-induced obese Lewis and F344 rats. In a second set of experiments an i...